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Comparison of Allopurinol And Febuxostat in Asymptomatic Hyperuricemic Patientsand their Impact on Serum Creatinine
ISSN: 2617 - 9482
Publisher: author
Comparison of Allopurinol And Febuxostat in Asymptomatic Hyperuricemic Patientsand their Impact on Serum Creatinine
Indexed in
Health Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 3
Article Operation Score: 3
Article Articles Score: 2
Article Accessibility Score: 2
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-0702
Publisher: Bahria University Medical And Dental College
International Journal Address (IAA):
IAA.ZONE/261797869482
eISSN
:
2617 - 9482
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ISSN Validator
Abstract
Objective: To determine the effect of Allopurinol & Febuxostat for the treatment of hyperuricemic patients & its influenceon renal function by measuring serum creatinine level.Study Design & setting: The clinical trial was conducted at Dr. Ruth K M Pfau Civil Hospital, Karachi, during the periodof September 2018 to March 2019Methodology: 60 patients with sUA > 6.8 mg/dl were registered. A detailed history was taken, patient's baseline serumUric Acid (sUA) & serum Creatinine were measured. Patients were divided into two groups to receive Allopurinol, 300mg & Febuxostat 80 mg, daily for 90-days. The blood parameters were repeated at day 30 and 90.Results: Group-A (Allopurinol treated patients) baseline uric acid changed from mean 8.79 ± 0.98 mg/dl to 6.40 ± 0.86mg/dl at day 90. In Group-B (Febuxostat treated patients) sUA baseline mean changed from 8.85 ± 0.97 mg/dl to 5.96 ±0.68 mg/dl. Mean difference ± SD change of serum uric acid in ...
