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Expression of Cyclin D1 in Hyperplastic and NeoplasticEndometrial Lesions
ISSN: 2617 - 9482
Publisher: author
Expression of Cyclin D1 in Hyperplastic and NeoplasticEndometrial Lesions
Indexed in
Health Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 3
Article Transparency Score: 2
Article Operation Score: 2
Article Articles Score: 3
Article Accessibility Score: 2
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-0702
Publisher: Bahria University Medical And Dental College
International Journal Address (IAA):
IAA.ZONE/2617100039482
eISSN
:
2617 - 9482
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ISSN Validator
Abstract
ABSTRACT:Objective: To observe and evaluate the expression of Cyclin D1 in hyperplastic and neoplastic endometrial lesions.Methodology: This .retrospective analytical study was conducted at BMSI, JPMC over a five year period i.e. from 1-1-2008to 31-1-2012 and was based on the analysis of endometrial samples comprising of hysterectomies and curettage. 55 endometrialsamples including 25 malignant endometrial lesions, 6 complex hyperplasia with atypia, 14 complex hyperplasia without atypia,6 simple hyperplasia without atypia, and 4 normal proliferative endometrium were analyzed for results of immunohistochemicalstaining.Results: 44% (11 out of 25) cases of malignant endometrial lesions showed Cyclin D1 over expression. 66.66% (4 out of 6)cases of endometrial hyperplasia with atypia and 50% (7 out of 14) cases of endometrial hyperplasia without atypia showedCyclin D1 overexpression.Conclusion: Cyclin D1 overexpression was seen in a signif...
