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Study of a Nano-Oleuropein's Effect on the TCA Cycle`s Protein Expression in the Breast Cancer Cell Line Using Proteom...
ISSN: 2292 - 2598
Publisher: author
Study of a Nano-Oleuropein's Effect on the TCA Cycle`s Protein Expression in the Breast Cancer Cell Line Using Proteom...
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Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 2
Article Operation Score: 2
Article Articles Score: 2
Article Accessibility Score: 2
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International Category Code (ICC):
ICC-1702
Publisher: Lifescience Global Inc.
International Journal Address (IAA):
IAA.ZONE/2292110362598
eISSN
:
2292 - 2598
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Abstract
Breast cancer is the most common cancer and a common cause of death, which occurs due to cancer among women in the world. Cancer cells need a lot of energy to their uncontrolled growth, so it seems that the expression of the enzyme in the Krebs cycle is changing. There are some reports about mutations and altered expression of succinate dehydrogenase, fumarate Hydratase, and isocitrate dehydrogenase in human cancers. This research aimed to investigate the role of magnetite nanoparticle Oleuropein on the Krebs cycle proteins expression on the breast cancer cell line. Oleuropein is one of the polyphenolic components in olive trees and has some benefits in some diseases, including cancer. In addition to testing the viability test MTT (3- 4,5 Dimethylthiazol-2-yl -2,5-diphenyltetrazolium bromide) assay, in three levels of Oleuropein 0ppm, 300ppm, 600ppm proteomics analysis was also performed in cell line MCF7 in this study. The results of...
