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Public Paper
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    Modeling, ADME and QSAR studies on Dihydroisoxazole derivatives as Transglutaminase-2 Inhibitors against Neurodegenera...

     
     
         
    ISSN: en

    Publisher: author   

Modeling, ADME and QSAR studies on Dihydroisoxazole derivatives as Transglutaminase-2 Inhibitors against Neurodegenera...
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Abstract Transglutaminase 2 is a member of the transglutaminase family, which helps in catalyzing the thiol- dependent transamidation reactions. It is the most ubiquitously expressed and most studied member of the family. An important role of the protein is the prevention of tissue injury, inflammation and autoimmunity once the apoptosis has already been initiated. This function is partially achieved by being expressed and activated in macrophages digesting apoptotic cells and mediating a crosstalk between dying and phagocytic cells. Transglutaminase 2 plays the main role in the pathogenesis of Alzheimer’s disease and Huntington’s disease by cross-linking proteins into insoluble polymers. Dihydroisoxazole derivatives have been tested for their potency against neurodegenerative disorders. Molecular docking studies have been carried on the (dihydroisoxazole derivatives) inhibitors using Schrödinger Suite 2009 against the target protein Tran...

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International Category Code (ICC):
ICC-0202
Sibi Narayanan, Velmurugan Devadasan
International Article Address (IAA): IAA.ZONE/en8280en
Paper Profile: Private
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Paper Evaluation: Pending
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