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Antioxidant Activity of Apocynin against Intestinal Ischemia-Reperfusion Induced Oxidative Damage in Lung and Intestin...
ISSN: 2687 - 5365
Publisher: author
Antioxidant Activity of Apocynin against Intestinal Ischemia-Reperfusion Induced Oxidative Damage in Lung and Intestin...
Indexed in
Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 3
Article Transparency Score: 3
Article Operation Score: 2
Article Articles Score: 3
Article Accessibility Score: 2
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1702
Publisher: International Journal Of Academic Medicine And Pharmacy Ne..
International Journal Address (IAA):
IAA.ZONE/268781975365
eISSN
:
2687 - 5365
VALID
ISSN Validator
Abstract
Potential effects of Apocynin against intestinal ischemia reperfusion-related oxidative damage was investigated in intestinal and lung tissues. Intestinal ischemia-reperfusion model was established. The superior mesenteric artery was occluded via an atraumatic clamp for 1 hour. Following ischemia, reperfusion was allowed for 2 hours. After the experimental processes, the animals were immolated, intestinal and lung tissue samples were removed. MPO activity and TOS, MDA, OSI, TNF-α, IL-1β levels raised in the ischemia-reperfusion group while TAS level and SOD activity diminished. TAS value and SOD activity elevated while MPO activity, OSI, TOS, TNF-α, IL-1β, and MDA levels decreased in low and high doses of Apocynin (20 mg/kg and 50 mg/kg) groups. Different doses of Apocynin administration demonstrated beneficial effects against intestinal ischemia reperfusion-induced oxidative damage in intestinal and lung tissues.
