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Hesperidin Attenuates Oxidative Ovarian Damage Induced by Ischemia Reperfusion: An Antioxidant, Antiautophagic and Ant...
ISSN: 2687 - 5365
Publisher: author
Hesperidin Attenuates Oxidative Ovarian Damage Induced by Ischemia Reperfusion: An Antioxidant, Antiautophagic and Ant...
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Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 3
Article Transparency Score: 2
Article Operation Score: 3
Article Articles Score: 3
Article Accessibility Score: 3
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1702
Publisher: International Journal Of Academic Medicine And Pharmacy Ne..
International Journal Address (IAA):
IAA.ZONE/268781925365
eISSN
:
2687 - 5365
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Abstract
In the current study, it was examined the possible protective properties of hesperidin (HES), an antioxidant, antiautophagic, and antiapoptotic molecule, against ovarian injury caused by ischemia reperfusion. 24 healthy rats were grouped as the group I (sham), group II (ischemia reperfusion (I/R)) and group III (I/R+HES) (n=8). In the sham group, the only abdominal incision was performed and closed. In the I/R group, following the incision, the I/R model was carried out. In the I/R+HES group, HES was administered intraperitoneally to the animals at the dose of 100 mg/kg approximately 1 hour before reperfusion. All the experimental procedures were performed under anesthesia. Following reperfusion, ovarian tissues were removed, and then some antioxidant, oxidant, autophagic and apoptotic parameters were evaluated. The oxidant parameters elevated, and antioxidant parameters declined in the I/R group. On the other side, antioxidant parame...
