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Gastroprotective Effects of Pear (Pyrus Communis L.) Extract on Ethanol Induced Gastric Ulcer in Rats
ISSN: 2687 - 5365
Publisher: author
Gastroprotective Effects of Pear (Pyrus Communis L.) Extract on Ethanol Induced Gastric Ulcer in Rats
Indexed in
Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 3
Article Transparency Score: 3
Article Operation Score: 2
Article Articles Score: 3
Article Accessibility Score: 2
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1702
Publisher: International Journal Of Academic Medicine And Pharmacy Ne..
International Journal Address (IAA):
IAA.ZONE/268781885365
eISSN
:
2687 - 5365
VALID
ISSN Validator
Abstract
Various natural molecules have been examined against ethanol-induced gastric ulcer up to present. Pear, Pyrus communis L. (PYR), includes various antioxidant and anti-inflammatory features. Current study was planned to find out potential preventive properties of PYR extract against gastric ulcer induced by ethanol in rats. 32 rats were assigned to 4 groups (n=8). Group I was sham, group II was ulcer group. Groups III and IV were 4 and 8 ml/kg PYR groups. Group I, normal saline was administered and group II, III and IV were administered ethanol (5 ml/kg) by oral gavage to rats. Phenolic substances in PYR content were detected via high-pressure liquid chromatography (HPLC). CUPRAC, ABTS and FCR amounts of PYR extract were determined. Gastric tissue was evaluated through macroscopic and immunohistochemical methods. NF-kB and caspase-3 expressions increased in ulcer group but PYR treatment reversed these levels. PYR extract performed prot...
