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Evaluation of Serum Interleukin-10, Tumor Necrosis Factor Alpha Level and Cardiovascular Autonomic Functions in Multip...
ISSN: 2687 - 5365
Publisher: author
Evaluation of Serum Interleukin-10, Tumor Necrosis Factor Alpha Level and Cardiovascular Autonomic Functions in Multip...
Indexed in
Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 2
Article Operation Score: 2
Article Articles Score: 3
Article Accessibility Score: 2
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1702
Publisher: International Journal Of Academic Medicine And Pharmacy Ne..
International Journal Address (IAA):
IAA.ZONE/268771105365
eISSN
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2687 - 5365
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Abstract
In relapsing-remitting multiple sclerosis (RRMS), the autonomic nervous system (ANS) can be affected and may deteriorate the disability of patients. Evaluation and management of autonomic dysfunction may improve quality of life of patients. We aimed to assess the autonomic dysfunction via heart rate variability (HRV) along with serum tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) levels and disclose the correlations between HRV and levels of these two chief biomarkers in the immunopathology of MS, if any. Thirty-six consecutive RRMS patients who had an EDSS score of 0-3 EDSS, not in the relapse period and receiving interferon beta treatment were compared with age and gender-matched 37 healthy subjects in terms of HRV, serum TNF- and IL-10 levels. ANS was evaluated by frequency-based HRV analysis. TNF-α and IL-10 levels in serum were measured by the ELISA method. The mean serum TNF-α level was found to be higher in the ...
