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Role of Nasal AQP5 And TREK1 Expression in Biomolecular Background of Pregnancy Rhinitis
ISSN: 2687 - 5365
Publisher: author
Role of Nasal AQP5 And TREK1 Expression in Biomolecular Background of Pregnancy Rhinitis
Indexed in
Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 3
Article Transparency Score: 3
Article Operation Score: 3
Article Articles Score: 3
Article Accessibility Score: 3
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1702
Publisher: International Journal Of Academic Medicine And Pharmacy Ne..
International Journal Address (IAA):
IAA.ZONE/268771095365
eISSN
:
2687 - 5365
VALID
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Abstract
Pregnancy rhinitis may lead predisposition to Obstructive Sleep Apnea Syndrome which is associated with critical comorbidities effecting both mother (preeclampsia, hypertension) and newborn (intrauterine growth retardation, low apgar score). We aim to unveil if nasal TREK-1 and AQP5 expression changes during pregnancy. We proposed that these two proteins may take part in the biomolecular background of Pregnancy Rhinitis. Twenty adult Wister albino female rats were enrolled into the study. Two groups constituted as 10 control (group A) and 10 pregnant (group B) rats. We sacrificed the rats at 21th day of gestation by intraperitoneal injection of 400mg/kg Na-pentobarbitone. Intracardiac blood sample was taken before the pulse died out. Serum estradiol (E2) and progesterone (PG) levels were determined by ELISA. Nasal septum with its mucoperichondrium was resected and sent for real time polymerase chain reaction testing. Relative TREK-1 (...
