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Investigation of the Curative Effect of Urapidil on Intestinal Inflammation and Oxidative Damage: An Experimental Study
ISSN: 2687 - 5365
Publisher: author
Investigation of the Curative Effect of Urapidil on Intestinal Inflammation and Oxidative Damage: An Experimental Study
Indexed in
Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 3
Article Operation Score: 3
Article Articles Score: 3
Article Accessibility Score: 3
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1702
Publisher: International Journal Of Academic Medicine And Pharmacy Ne..
International Journal Address (IAA):
IAA.ZONE/268751175365
eISSN
:
2687 - 5365
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ISSN Validator
Abstract
The antioxidant effects of urapidil were investigated histopathologically and biochemically on the intestinal tissue that underwent ischemia-reperfusion injury. 40 Wistar albino female rats were divided into sham operation (Group 1), ischemia-reperfusion (Group 2), ischemia-reperfusion plus dimethyl sulfoxide (Group 3), ischemia-reperfusion plus urapidil 0,5 mg/kg (Group 4), and ischemia-reperfusion plus urapidil 5 mg/kg (Group 5). All rats except group 1 had 1h ischemia followed by 2h reperfusion to investigate the effects of urapidil through TAS, TOS, MDA, MPO, SOD, NF-κB, caspase-3, and LC3B. In terms of immunohistochemical staining with caspase 3, NF-κB and LC3B there was a statistical difference in group 1 compared with other groups (p
