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Analysis of TET-2, ASXL1, IDH1, IDH2 Gene Polymorphisms and The Correlation with Clinical Parameters in Patients With ...
ISSN: 2687 - 5365
Publisher: author
Analysis of TET-2, ASXL1, IDH1, IDH2 Gene Polymorphisms and The Correlation with Clinical Parameters in Patients With ...
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Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 3
Article Operation Score: 3
Article Articles Score: 2
Article Accessibility Score: 2
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1702
Publisher: International Journal Of Academic Medicine And Pharmacy Ne..
International Journal Address (IAA):
IAA.ZONE/268751135365
eISSN
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2687 - 5365
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Abstract
Myelodysplastic syndrome (MDS) represent heterogeneous group of disorders with a variety of features including peripheral cytopenia, characteristic morphological findings and cytogenetic abnormalities in bone marrow. Some genes are reported to be involved in the pathogenesis of MDS such as IDH1-2, TET2 and ASXL1. Thus, identifying the recent mutations of these genes and genotyping the patients for these mutations might have clinical impact in MDS. We aimed to determine the genotype distribution and allele frequency of selected genes in MDS cases. Total 100 patients were genotyped for 5 mutations. For DNA isolation was peripheral blood was used. The cases were genotyped with sequence detection Systems software for allelic discrimination for each mutation. Age at diagnosis, gender, WHO classification, IPSS group, diagnosis (WBC-Hb-PLT) compared with polymorphisms (wild-type, heterozygous, homozygous mutants) were not statistically signi...
