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Comparison of the metabolic effects of eplerenone and spironolactone via plasma galectin-3 level in patients with hear...
ISSN: 2148 - 9211
Publisher: author
Comparison of the metabolic effects of eplerenone and spironolactone via plasma galectin-3 level in patients with hear...
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Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 2
Article Operation Score: 3
Article Articles Score: 2
Article Accessibility Score: 2
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1702
Publisher: Cardiovascular Surgery And Interventions Bayçınar Medica..
International Journal Address (IAA):
IAA.ZONE/214848909211
eISSN
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2148 - 9211
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Abstract
Objectives: This study aims to compare the metabolic effect of eplerenone and spironolactone, mineralocorticoid receptor blockers, in patients with heart failure via galectin-3 plasma level. Patients and methods: Between March 2018 and July 2018, 20 heart failure patients (12 males, 8 females; mean age 65.2±7.6 years; range, 58 to 73 years) diagnosed based on clinical parameters and echocardiographic findings were randomized (1:1) to either spironolactone (25 mg/day) or eplerenone (50 mg/day). All patients were also given standard heart failure treatment. We measured plasma levels of galectin-3 with biochemically. Galectin-3 levels were compared before the study and four months after both spironolactone and eplerenone treatment. Results: The mean ejection fraction of the patients was 25.0±4.6% in the eplerenone group and 25.0±4.7% in the spironolactone group. Demographic and hemodynamic characteristics of the patients were comparab...
