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The Influence of Gene Mutations on Bone and Teeth: Osteogenesis and Dentinogenesis Imperfecta
ISSN: 2582 - 6751
Publisher: author
The Influence of Gene Mutations on Bone and Teeth: Osteogenesis and Dentinogenesis Imperfecta
Indexed in
Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 3
Article Operation Score: 3
Article Articles Score: 2
Article Accessibility Score: 3
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1702
Publisher: Athenaeum Scientific Publishers
International Journal Address (IAA):
IAA.ZONE/2582117566751
eISSN
:
2582 - 6751
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Abstract
Abstract Osteogenesis Imperfecta (OI) are inherited disordesr generating skeletal fragility. It is caused by mutations in one of the two genes encoding type I collagen (COL-1A1, COL1A2). Four subtypes of OI has been identified: Classic non-deforming OI with blue sclerae (Type I), perinatally lethal OI (Type II), progressively deforming OI (Type III) and common variable OI with normal sclerae (Type IV). Type IV comprises patients with phenotype intermediate to types I and III. More recently, other types of OI (V-XV) have been reported. Although they phenotypically resemble to types I-IV, they are not associated to type I collagen mutations. Dentinogenesis Imperfecta (DI), associated or not with OI, was classified in five types: Dentin Dysplasia types I and II (DD1 and DD2) and Dentinogenesis Imperfecta (DGI-types I-III). Cleavage of DSPP gives rise to three molecules susceptible to mutations, respectively dentin sialoprotein (DSP), Den...
