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Osmolality Threshold for Sickle Cell Erythrocyte Hemolysis
ISSN: 2582 - 6751
Publisher: author
Osmolality Threshold for Sickle Cell Erythrocyte Hemolysis
Indexed in
Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 3
Article Transparency Score: 3
Article Operation Score: 2
Article Articles Score: 3
Article Accessibility Score: 2
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International Category Code (ICC):
ICC-1702
Publisher: Athenaeum Scientific Publishers
International Journal Address (IAA):
IAA.ZONE/2582117516751
eISSN
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2582 - 6751
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Abstract
Abstract Background: The importance of fluid intake is well document as metabolic and physiological processes operate effectively in a homeostatic environment. Normal red cells are more resilient to changes in serum osmolality compared to other cells, remaining intact when serum osmolality decreases to as low as 190-mOsM from the 270-290-mOsM reference interval. The membrane’s ability to deform/reform under shear confers the red cell high resistant to changes in serum osmolality. Although normal red cells are resilient, the osmolality threshold for hemolysis of abnormal red cells such as sickle cell blood remains unclear. The primary objective of this study was to determine the osmolality threshold for hemolysis of sickle cell blood vis-a-vis that of normal red cells. Methods: As described under methods, red cells were prepped and exposed to solution of varying osmolality ranging from 290 to 65-mOsm of sodium chloride. Following incub...
