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Sickle Cell Anemia: A Succinct Look into Recently Tested Disease Modifying Interventions
ISSN: 2582 - 6751
Publisher: author
Sickle Cell Anemia: A Succinct Look into Recently Tested Disease Modifying Interventions
Indexed in
Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 2
Article Operation Score: 3
Article Articles Score: 2
Article Accessibility Score: 3
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1702
Publisher: Athenaeum Scientific Publishers
International Journal Address (IAA):
IAA.ZONE/2582117436751
eISSN
:
2582 - 6751
VALID
ISSN Validator
Abstract
Abstract Sickle Cell Anemia (SCA) is a globally prevalent, monogenic, life-threatening blood disorder with a complex pathology that remains obscure. A deepened understanding of the malady in the recent years has led to pharmaceutical advancements that target pathophysiology and ultimately ameliorate associated multivariate clinical manifestations. Abnormal cell to cell interactions, endothelial adhesion, induced oxidative stress, intracellular erythrocyte dehydration and concentration levels of fetal hemoglobin are a few factors know to play a key role in microvascular obstruction in individuals with hemoglobin S. All of which have recently been manipulated in-vitro to pharmaceutically alter clinical complications, disease progression and mortality patterns. The purpose of this paper is to provide a condensed overview of recent discoveries made within SCA pathology and subsequent pathologic based therapeutic agents. A general overview...
