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Transforming Growth Factor-Beta (TGF-β) Employs Epithelial-Mesenchymal Transition (EMT)-Inducible Cancer Cells to Secr...
ISSN: 2687 - 5365
Publisher: author
Transforming Growth Factor-Beta (TGF-β) Employs Epithelial-Mesenchymal Transition (EMT)-Inducible Cancer Cells to Secr...
Indexed in
Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 3
Article Operation Score: 3
Article Articles Score: 3
Article Accessibility Score: 2
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1702
Publisher: Necati Ozpinar
International Journal Address (IAA):
IAA.ZONE/2687103255365
eISSN
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2687 - 5365
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ISSN Validator
Abstract
Epithelial–mesenchymal transition (EMT) is a vital program required for cancer invasion and metastasis. EMT inducer transforming growth factor-beta (TGF-β) is implicated in carcinogenesis by contributing metastasis, immune evasion, and immunosuppression. Cancer cells employ different mechanisms to suppress the differentiation and the activation of immune system cells. Recent studies have reported that exosomes derived from cancer cells induced by several internal and external factors may suppress the immune system. We aimed to illustrate whether TGF-β recruits cancer cells to secrete several miRNAs that could suppress the immune system. We performed all experiments with TGF-β-responsive (A549) non-small cell lung cancer and (PANC-1) pancreatic ductal adenocarcinoma cell lines used as in vitro models. We isolated exosomes secreted by TGF-β-induced cells. We analyzed miRNAs in exosomes by qPCR. We showed that miR-1246 was significantly ...
