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Brine Shrimp Lethality Bioassay: A Tool for Drug Discovery from Natural Products
ISSN: 2026 - 6480
Publisher: author
Brine Shrimp Lethality Bioassay: A Tool for Drug Discovery from Natural Products
Indexed in
Chemistry Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 3
Article Transparency Score: 2
Article Operation Score: 2
Article Articles Score: 2
Article Accessibility Score: 3
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-0602
Publisher: Koforidua Technical University
International Journal Address (IAA):
IAA.ZONE/2026393506480
eISSN
:
2026 - 6480
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ISSN Validator
Abstract
This study demonstrates the importance of the Brine Shrimp Bioassay in drug discovery. It uses two medicinal plants, Zanthoxylum xanthoxyloides and Tiliacora funifera. Extracts of Zanthoxylum xanthoxyloides were prepared using water, ethanol, chloroform and diethylether, and each subjected to Brine Shrimp Bioassay. The bioactivities of the extracts were found to be in the order diethylether (LD50=0.958 mg/ml), followed by ethanol (LD50=1.874 mg/ml), water (LD50=2.322 mg/ml), and chloroform (3.518 mg/ml). From Tiliacora funifera is isolated the compound funiferine, which is derivatized to obtain o-methylfuniferine and o-isopropylfuniferine. These were subjected to the brine shrimp bioassay, and the structure
