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Formulation development and in vitro evaluation of oral dispersible tablets of Olanzapine by direct compression
ISSN: 2456 - 8244
Publisher: author
Formulation development and in vitro evaluation of oral dispersible tablets of Olanzapine by direct compression
Indexed in
Biology and Life Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 2
Article Operation Score: 3
Article Articles Score: 3
Article Accessibility Score: 3
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-0402
Publisher: Rb Science
International Journal Address (IAA):
IAA.ZONE/245695888244
eISSN
:
2456 - 8244
VALID
ISSN Validator
Abstract
The objective of the present work was to formulate mouth dissolving tablet enriched with taste masking agent to provide rapid onset of action of olanzapine increasing its therapeutic efficacy and also increase the compliance amongst geriatric, pediatric and uncooperative patients. Precompression blends of the ODTs were prepared and evaluated for its micromeritic properties. Total four formulations of ODTs were prepared using direct compression (OLODT1 to OLODT4) method. The concentration of the super-disintegrant was varied for formulating the blends. Mannitol was used as the binder as well as sweetener while saccharin sodium was used as the additional taste masking agent in the formulations. All the formulations were subjected to post compression evaluation test and the results indicate that the formulation had hardness of 3 Kg/cm2, thickness of 3 mm, weight variation in the range of 4.1-5.3 %, friability of less than 1 %, drug conte...
