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Testicular and Epididymal Toxicity of Carbaryl in Sprague-Dawley Strain Rats
ISSN: 0976 - 7614
Publisher: author
Testicular and Epididymal Toxicity of Carbaryl in Sprague-Dawley Strain Rats
Indexed in
Biology and Life Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 2
Article Operation Score: 2
Article Articles Score: 3
Article Accessibility Score: 3
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-0402
Publisher: Journal Of Advanced Laboratory Research In Biology Society..
International Journal Address (IAA):
IAA.ZONE/097653367614
eISSN
:
0976 - 7614
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Abstract
In the past decade, the use of carbamate has become exceedingly popular as that of the organophosphates. There is a growing concern that the exposure to these compounds is a chronic hazard to man and animals. The present study was conducted to investigate the testicular and epididymal toxicity of carbaryl on rats. Male rats of Sprague-Dawley strain were administered orally with carbaryl dissolved in olive oil at 50 - 150mg doses/Kg body weight/day for 30 days. At the end of the treatment, rats were weighed and killed. Body weights remained unchanged at the end of the treatment. The weights of testis and epididymis decreased significantly after the treatment along with significant reductions in epididymal sperm count, viability and sperm motility. Activities of 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase showed a significant decrease along with the reduction in the serum pituitary LH, FSH and testosterone. Ca...
